What is PANAXYNOL and where is it commonly found?
PANAXYNOL, also known as carotatoxin or falcarinol, is a polyacetylene compound predominantly found in the Apiaceae and Araliaceae plant families. It is prominently found in American ginseng, among other plants, and is known for its various medicinal properties.
What are the primary health benefits associated with PANAXYNOL?
PANAXYNOL is renowned for its anti-inflammatory, anti-tumor, and potentially neuroprotective effects. It has demonstrated utility in improving intestinal barrier function, reducing inflammation in various models, and exhibiting cytotoxic activity against several human tumor cell lines.
How does PANAXYNOL exhibit anti-tumor activity?
The anti-tumor properties of PANAXYNOL are linked to its ability to reduce cyclin E mRNA expression, decrease cell proliferation, and interact with the ATP-binding pocket of HSP90 homodimers. This interaction impairs angiogenesis and affects cancer stem cells and non-cancer stem cell populations, particularly in non-small cell lung cancer, without inducing HSP70 expression.
In what ways does PANAXYNOL support intestinal health?
PANAXYNOL has been shown to enhance intestinal barrier function and improve conditions like colitis. It does so by improving colonic crypt and mucosal architecture, suppressing colitis-related microbes, reducing the presence of macrophages, and promoting the differentiation of regulatory T-cells in the colonic lamina propria.
Does PANAXYNOL have any effects on cardiovascular or neurological health?
Yes, PANAXYNOL exhibits anti-inflammatory effects in models of inflamed macrophage-induced cardiomyocyte hypertrophy. Additionally, it has neuroprotective activities, suggesting potential benefits in neurological health maintenance.
How does PANAXYNOL interact with inflammatory responses in the body?
PANAXYNOL demonstrates anti-inflammatory properties by upregulating the Nrf2/HO-1 pathway. This reduces the levels of inflammatory cytokines, lipid peroxidation, and inflammatory cell infiltration, thereby mitigating inflammation in various models, including intestinal inflammation.
